Search Result "the half-life for clearance"


General Review Article

Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins

Journal: Current Pharmaceutical Design
Volume: 24 Issue: 4 Year: 2018 Page: 4932-4946
Author(s): Huanbo Tan,Wencheng Su,Wenyu Zhang,Pengju Wang,Michael Sattler,Peijian Zou

Review Article

Optimization of Protein and Peptide Drugs Based on the Mechanisms of Kidney Clearance

Journal: Protein & Peptide Letters
Volume: 25 Issue: 6 Year: 2018 Page: 514-521
Author(s): Jiaguo Huang,Huizi Wu

Review Article

New Directions for Half-Life Extension of Protein Therapeutics: The Rise of Antibody Fc Domains and Fragments

Journal: Current Pharmaceutical Biotechnology
Volume: 17 Issue: 15 Year: 2016 Page: 1348-1352
Author(s): Lili Wang,Tianlei Ying

Predicting Clearance in Humans from In Vitro Data

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 334-339
Author(s): R. Scott Obach

ARC - Augmented Renal Clearance

Journal: Current Pharmaceutical Biotechnology
Volume: 12 Issue: 1 Year: 2011 Page: 2020-2029
Author(s): Andrew A. Udy, Michael T. Putt, Robert J. Boots, Jeffrey Lipman

Application of Simple Mathematical Expressions to Relate Half-Lives of Drugs in Mice to Those in Humans

Journal: Drug Metabolism Letters
Volume: 1 Issue: 2 Year: 2007 Page: 127-129
Author(s): Kenneth Bachmann, Jonathan Chupka, Paul Erhardt, Donald White

Scaling In Vivo Pharmacokinetics from In Vitro Metabolic Stability Data in Drug Discovery

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 13 Issue: 2 Year: 2010 Page: 159-169
Author(s): Wendy Klopf, Philip Worboys

Granulocyte Apoptosis and Macrophage Clearance of Apoptotic Cells as Targets for Pharmacological Intervention in Inflammatory Diseases

Journal: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Volume: 5 Issue: 1 Year: 2006 Page: 3-12
Author(s): Nicola A. Riley, Carol Ward, Deborah A. Sawatzky, Tara A. Sheldrake, Ian Dransfield, Christopher Haslett, Adriano G. Rossi

Systematic and Pairwise Analysis of the Effects of Aromatic Halogenation and Trifluoromethyl Substitution on Human Liver Microsomal Clearance

Journal: Drug Metabolism Letters
Volume: 5 Issue: 4 Year: 2011 Page: 232-242
Author(s): Hao Sun, Christopher E. Keefer, Dennis O. Scott

Controversies in Allometric Scaling for Predicting Human Drug Clearance: An Historical Problem and Reflections on What Works and What Does Not

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 340-350
Author(s): Huadong Tang, Michael Mayersohn

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